I wonder how the interaction between Nocturnal will go now that Karliah is the Dragonborn? Does Nocturnal reject her from the Evergloam since her soul will go to Akatosh first? Or will she just treat it as another soul? Whilst the former would be make for an interesting side-story, the latter would e more useful if you want to concentrate on more exciting parts of her adventure without going into details of being denied from Nocturnal's embrace.

Also, try not to be intimidated by the Wolf Queen Awakens (if you are). Just write your story and avoid comparing it with the other and going "Oh no, that story is better than mine. Better stop writing."